Effect of Nociceptin on Orexin Neurons
When organisms are exposed to stress, the stress may lead to pain suppression. This phenomenon is known as stress-induced analgesia (SIA), a key defensive mechanism for coping with stress, although excessive SIA may be detrimental. The cellular mechanism by which SIA is induced is not well known. Orexin is a neurotransmitter expressed in the brain that is known to be activated by stressful stimuli and induce analgesia. Furthermore, it has been shown that SIA is reduced in animals that lack orexin. Therefore, orexin plays a key role in SIA. We are investigating the cellular mechanisms by which effects of pain modulators such as nociceptin are integrated by orexin-expressing neurons. Understanding the cellular and molecular mechanisms underlying SIA may lead to development of novel strategies for pain management.
30 Nov -0001
Portugal Cove-St. Phillips, NL
Strategic Research Theme
Well-being, Health and Biomedical Discovery