Genetic Prognostic Factors in Colorectal Cancer Patients from Newfoundland and Labrador
In Newfoundland and Labrador (NL), colorectal cancer is a serious public health concern because both the incidence and the death rates of this disease are higher than in the rest of the country. Cancer survival is modified by a variety of factors, including genetic factors. Identification of these genetic factors plays a critical role in selection of appropriate treatment regimen and delivering the most effective medical care to patients. However, majority of the genetic factors influencing survival in colorectal cancer is currently unknown. In our studies, in collaboration with the Newfoundland Familial Colorectal Cancer registry, we investigate the genetic variations from select genes and their correlation with length of survival in colorectal cancer patients from NL. Once confirmed in larger studies, results of our study may be used to select the best possible treatment for each colorectal cancer patient. For example, the patients whose genotypes predict worse survival can be treated with more aggressive therapies, whereas patients with favorable genotypes can be spared of unnecessary treatments. Therefore, by expediting a personalized medicine approach, results of this study may improve the patient survival in colorectal cancer.
30 Nov -0001
Clinical Disciplines - Genetics
St. John's, NL
Strategic Research Theme
Well-being, Health and Biomedical Discovery