Studying the associations of copy number variations (CNVs) with patient outcomes in colorectal cancer
Since genetic characteristics of patients can biologically modify the risk of outcome, genetic variations are candidate prognostic markers in colorectal cancer. Copy number variations (CNVs) that contain DNA fragments (up to several megabases) are recently discovered genetic variations. In a previous study, we had detected the CNVs in the genomes of 495 colorectal cancer patients from Newfoundland and Labrador (NL). In this study, we propose to investigate the associations of CNVs that have potential biological consequences (i.e. affect gene sequences) with the patient outcomes (i.e. recurrence and death) using statistical methods.
21 Jul 2014
01 Aug 2019
Medical Research Fund - Memorial University
Strategic Research Theme
Well-being, Health and Biomedical Discovery