Prostaglandin-E2-mediated activation of melanin-concentrating hormone neurons in diet-induced obesity

Lay Summary 

During the past few decades, the rate of obesity has tripled worldwide. This is detrimental as obesity is a major risk factor for many non-communicable diseases including type 2 diabetes, cardiovascular diseases, and some cancers. Despite the prevalence of obesity, there are few therapeutic interventions available for individuals. Bodyweight is controlled by the brain, specifically by appetite-promoting or appetite-suppressing brain cells that are found in the hypothalamus. We have found that a group of appetite-promoting brain cells called melanin-concentrating hormone (MCH) neurons become active after eating high-fat diet (HFD). This activation is due to prostaglandin E2, a molecule involved in inflammation. Therefore, my project focuses on (1) further investigating the inflammatory effect of HFD on the hypothalamus, (2) understanding the way HFD activates MCH neurons, and lastly (3) testing whether preventing the effect of prostaglandin E2 on MCH neurons can be protective against obesity. Overall, this research aims to identify a novel therapeutic intervention for individuals with obesity. 


Adapted from

BioMedical Sciences
Canadian Institutes Of Health Research
St. John's
Newfoundland and Labrador
Mental Health
Industry Sectors 
Health Care and Social Assistance
Start date 
1 Sep 2019
End date 
31 Aug 2022
Lead Organization 
Faculty of Medicine, Memorial University